Just started using Tweetdeck to run my Twitter account (JohnAscroft if you're interested).
What a great little product. I am constantly amazed how much good free stuff there is out there.
TweetDeck lets you set up columns of things you are interested in, so I have columns of - friends timeline, direct messages, mentions and a couple of live searches. Also, you can hook in LinkedIn and Facebook, so I have a column showing LinkedIn updates.
This is pretty cool, so I get an alert whenever anything I am interested in happens and it all just runs quietly in the background.
If you're still using the standard web interface to Twitter, I can recommend this as a definite step up.
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